Relationship between biochemical markers and measles viral load in patients with immunologically naive cases and secondary vaccine failure: LDH is one of the potential auxiliary indicators for secondary vaccine failure

This study investigated the correlation between biochemical markers and viral load among 38 measles cases, including 15 immunologically naive patients 23 with secondary vaccine failure (SVF). We examined four markers, namely, aspartate aminotransferase, alanine C-reactive protein, lactate dehydrogenase (LDH) their relationship virus genome copy numbers in peripheral blood mononuclear cells (PBMCs) throat swabs as well concentration of measles-specific IgG. Although copies both clinical specimens showed a significant specific IgG concentration, they had higher PBMCs (Pearson's product-moment coefficient, −0.662; p < .0001) than (Spearman's rank −0.443; = .0078). The also significantly correlated LDH values (correlation 0.360; .036). Thus, serum level might be potential auxiliary indicator to distinguish from those SVF.